From historical/anecdotal use, continuing cancer and antiviral research with Nerium oleander extracts, Nerium Biotechnology, Inc. (Nerium) has identified the potential for Nerium extract use in topical skincare applications. Product formulation provides for Nerium Extract to be the key ingredient in each product that will be designed and formulated for a specific target. This provides Nerium with the opportunity to develop for the consumer an ever expanding pipeline of natural botanical healthcare, topical, cosmetic and OTC skin products.
Historical Use (Nerium oleander plant)
Historical use of the Nerium oleander plant for medicinal applications has been reported in ancient texts and folklore for more than 1500 years. The Nerium oleander plant has been used traditionally as folk remedies for a wide variety of maladies and conditions, including dermatitis, eczema, psoriasis, herpes, sores, abscesses, warts, corns, skin cancer, ringworm, scabies, epilepsy, abortifacients, asthma, malaria dysmenorrheal, emetics, diuretics and heart tonics.
New Extraction Technology
In addition to the original aqueous extraction process, Nerium has developed a new technology; a patent-pending extraction process NBio-PL²™ (Plant-to-Plant extraction) that provides for the formulation of numerous new enhanced topical skincare products. This extraction technology incorporates pure liquid Aloe Vera (cold processed) as an extraction media to extract the unique Nerium oleander plant components in a way that preserves the unique and beneficial properties of both plants, without additional solvents. The result of this process combines the unique beneficial properties of the Nerium oleander plant with the known beneficial properties of the Aloe Vera plant, providing the extract NAE-8™ for topical product formulation.
Historical Use (Aloe Vera plant)
The Aloe Vera plant has been well known for centuries for its healing properties; the raw plant and commercial preparations can be used, and both oral intake and topical dressings have been documented to facilitate healing of any kind of skin wound, burn, or scald - even speeding recovery time after surgery. Historical use includes blisters, insect bites, rashes, sores, herpes, urticaria, athlete's foot, fungus, vaginal infections, conjunctivitis, sties, allergic reactions, and dry skin. Other topical uses include acne, sunburn, frostbite (it appears to prevent decreased blood flow), shingles, screening out x-ray radiation, psoriasis, preventing scarring, rosacea, warts, wrinkles from aging, and eczema. Top
Nerium’s initial topical/dermal formulations were provided for by Don Smothers, President, CEO of Natural Technology Incorporated (Naturtech) a GMP manufacturing facility. Mr. Smothers has more than 40 years experience in the formulation, development, and manufacturing of consumer products and also has more than 30 years of experience with Aloe Vera research, Aloe Vera industry affiliations, and Aloe Vera based consumer products.
Nerium’s initial basic formulations includes utilization of NaturTech’s proprietary naturally grown Aloe Vera processing technology, known as "cold processed, whole leaf aloe vera" as the extraction media with the patent-pending Extraction process NBio-PL²™ which were clinically tested for safety.
Today NaturTech provides for formulation and manufacturing of enhanced skin care products as Nerium moves forward with its topical cosmetic and OTC healthcare consumer products.
Safety and Clinical Testing
Research for product safety and application was initiated with ST&T Research (Science, Toxicology & Technology). ST&T Research is comprised of a group of prominent scientist, including M.D. and Ph.D. pharmacologists/toxicologist and research product development oriented physicians, scientist, and regulatory compliance specialists which include a legal team specializing in US FDA/FTC/Customs regulations. ST&T Research provides product development, product compliance, regulatory compliance, clinical testing, and information and data for safety and efficacy.
Dr. Robert A. Newman as scientific advisor to Nerium assisted by providing safety data from previous research, studies, and experience from the FDA safety trial at the University of Texas M. D. Anderson Cancer Center (MDACC). In addition, Dr, Newman provided the analytical method for determination of oleandrin (CG) in blood plasma and MDACC provided for blood analysis. ST&T Research initiated clinical human studies on various skin disorders (1. age/liver spots, actinic keratosis (2. acne vulgaris (3. sunburn (4. fever blisters / cold sores. The Nerium test article application was first applied as a spot treatment, then larger areas of skin application with each new clinical study. Two (2) of these clinical studies (acne, sunburn) included comparison to well-known OTC products currently available to consumers.
Each study's primary end-point was to evaluate the Nerium test articles for safety/toxicity, a) Determine if the Nerium oleander CG metabolites were being absorbed through the skin, b) If so, how much, c) If there was any noticeable blood pressure or heart rate changes, and d) If there were changes in blood chemistry or organ system functions. In addition, subjects were observed for inflammation, rash, or tenderness possibly related to the cream application.
ST&T Research utilized blood chemistry and CBC analysis whereby a comparison was made of the participant's baseline results with measurements taken throughout the study. As an example, participant blood samples were taken on day one (1) (one hour after cream application), day seven (7), day fifteen (15), and on day thirty (30) of product use to test for oleandrin (CG) absorption and accumulation in the blood.
Analysis was non-eventful. The blood analysis showed all subjects within normal ranges, there were no detectable CG's in the blood and no adverse reactions noted. With regard to efficacy, ST&T was surprised to find there were a statistically significant number of subjects reporting positive results since the Nerium test articles contained no "additives or cleansing compounds" like the OTC products.
Continuing research and trials for Nerium formulations are planned for not only topical cosmetic formulations but also healthcare OTC formulations. Nerium believes it will continue to demonstrate safety and new effective uses of its formulations.
Investigators: Science, Toxicology & Technology and its physicians / health care practitioners.
Sponsor: Nerium Biotechnology Inc. (Nerium)
New SkinCare Subsidiary
This research has led to the establishment of a new USA-based subsidiary of Nerium Biotechnology, Inc., Nerium SkinCare, Inc. Nerium SkinCare provides for the commercialization o f the “first of its kind” natural skincare products for topical use. Based on the core science and technology of Nerium, Nerium SkinCare now has the ability to formulate and develop a complete line of skincare product applications for both cosmetic and OTC natural products. Products with specific targets have been identified and are focused on sun-damaged aging skin, several specific skin diseases, antiviral conditions, and pre-skin cancers.Top
- Research Publications
- Cancer Research
- Skin Cancer Research
- Antiviral Research
- Skin Research
- Farm Operations Research
- Immune Research
Publication: In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin...
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Press Release: Nerium SkinCare, Inc. and Nerium International, LLC (NeriumAD - Age-Defying Treatment)
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NaturTech manufactures first commercial run of NeriumAD (Age –Defying Treatment / Night Cream)
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Final Report: Nerium AD clinical trial is completed. (See Final Report as well as clinical trial video.)
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Presentation Annual Meeting of the American Society of Clinical Oncology (ASCO)
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ST&T Research conducts NeriumAD Clinical Study.
Clinical research for NeriumAD product safety, efficacy, and dermal application was initiated with ST&T Research.
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Antiviral Research (HIV) – Animal Model Study Initiated
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